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KMID : 0380620190510010052
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Korean Journal of Food Science and Technology
2019 Volume.51 No. 1 p.52 ~ p.57
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Inhibitory effects of crude polysaccharide fractions from Annona muricata L. on melanogenesis
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Kim Yi-Eun
Byun Eui-Hong
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Abstract
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The objective of this study was to evaluate the anti-melanogenic effects of crude polysaccharide fractions from Annona muricata L. (ALP) in 3-isobutyl-1-methylxanthine (IBMX) stimulating hormone-induced mouse B16F10 melanoma cells. The inhibitory effect of ALP on tyrosinase activity was approximately 33.88±0.79% at 5 mg/mL. Additionally, the B16F10 cellular tyrosinase and melanin synthesis inhibition activities by ALP were 54.21±4.76 and 56.74±6.97% at 250 μg/mL, respectively. Similarly, whitening-related protein tyrosinase, tyrosinase-related protein 1 (TRP-1) and TRP-2, and microphthalmia-associated transcription factor (MITF) were reduced by ALP treatment. These results indicated that ALP could be used as a functional cosmetic ingredient after confirming its whitening activity related to melanin content.
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KEYWORD
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Annona muricata L., tyrosinase, melanin synthesis, whitening activity, microphthalmia-associated transcription factor (MITF)
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